International Journal For Multidisciplinary Research

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A Study of Correlation of Expression of Er, Pr & Her2neu Receptor Status with the Clinico-pathological Prognostic Factor in Breast Carcinoma

Author(s) Dr. ABHISHEK SINGH, Dr Samiksha singh
Country India
Abstract BACKGROUND: Breast cancer is the most common malignancy in females. It is routinely classified according to the WHO classification. However molecular classification can be more powerful than histopathology as a predictive factor for the different treatment strategies. Studies have shown that the triple negative breast cancer are more aggressive then others, likely to early metastasis & recur even after treatment.
AIMS: This study gives insight to overall prognosis, role of molecular markers, molecular subtype and better categorisation of triple negative cancer cases.
DESIGN: This was a retrospective study conducted in the Department of Pathology, Base Hospital Delhi Cantt over a period of 01 years from January 2018 to January 2019.
MATERIAL AND METHODS: In this study 50 cases of breast carcinoma were included. Molecular phenotype was determined by using expression of ER, PR and HER2/neu.
STATISTICAL ANALYSIS USED: Correlation of molecular subtype with histological grade, prognostic and predictive factor done by using chi square test.
RESULT: Out of 50 cases, maximum 24 number of cases were Luminal A and 13 were Basal Like. Invasive ductal carcinoma is most common (88%) followed by Mucinous carcinoma (4%) and invasive mammary carcinoma. Commonest histological subtype is IDC (NOS) grade III (58%) with coexisting intraductal component with IDC was seen in 60%. Extensive intraductal component noted in 24%. Lymhovascular invasion was found in 34% of cases. Lymph node metastasis was found in 58% of cases. Incidence of ER, PR & Her2neu positivity in study population was 58%, 44% & 24%.respectively. Triple negative cases constituted 26% of total cases. On molecular classification 26% cases were basal like, luminal A were 48 %, Her2neu type were 16% and luminal B were 10% of total cases. Commonest molecular class was luminal A followed by basal like. Most common histological subtype in basal like category was infiltrating duct carcinoma grade III followed by grade II. In Her2Neu category majority of cases were IDC Grade III followed by grade II. Statistically significant association of molecular subtype was found with histological subtype, lymph node involvement and lymphovascular invasion.
CONCLUSION: Molecular classification would help to determine the cases in which utilisation of chemotherapy is useful and with the help of it the prognosis in breast carcinoma can be determine. It help in the decision of requirement of the chemotherapy. In the present study significant group occurred in less than 45 years of age presenting in advanced stage of the disease. Triple negative cases were seen in 26% cases of infiltrating duct cell carcinoma indicating bad prognosis.

KEY MESSAGE: In view of increasing early presentation of breast cancer at a young age, the various screening program, breast self examination and self awareness with presence of family history should be popularized to early diagnosis and prevention.
Keywords KEYWORDS: Breast carcinoma, Clinicopathological parameters, Molecular classification, Hormonal status, Triple negative cases
Field Medical / Pharmacy
Published In Volume 7, Issue 5, September-October 2025
Published On 2025-10-13
DOI https://doi.org/10.36948/ijfmr.2025.v07i05.57818
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