Formulation and Evaluation of Novel Sublingual Tablet for Anxiety

Rohit Chourasiya; Rachana Akhand Giri; Shaili Dwivedi; Ajaytosh Raj Gupta

doi:10.36948/ijfmr.2025.v07i05.58043

Formulation and Evaluation of Novel Sublingual Tablet for Anxiety

Author(s)	Mr. Rohit Chourasiya, Dr. Rachana Akhand Giri, Ms. Shaili Dwivedi, Mr. Ajaytosh Raj Gupta
Country	India
Abstract	The current research centers on developing and assessing a new sublingual tablet designed for the swift treatment of anxiety disorders. Sublingual administration avoids hepatic first-pass metabolism, providing enhanced bioavailability and quicker therapeutic effects compared to traditional oral dosage forms. The tablets were produced via direct compression, utilizing super disintegrants such as croscarmellose sodium and crospovidone to facilitate rapid disintegration, and were subjected to comprehensive evaluations, including pre-compression, post-compression, dissolution, taste-masking, and stability assessments. Pre-compression investigation demonstrated superior flow properties of the powder blends, with an angle of repose between 25–29°, a Carr’s index below 15%, and a Hausner’s ratio of 1.12–1.20, validating their appropriateness for direct compression.. Post-compression assessments showed tablets with consistent hardness (3.0–3.5 kg/cm²), friability below 1%, and drug content uniformity within 98–102%. The optimized formulation achieved disintegration in under 30 seconds, essential for rapid relief during acute anxiety episodes. In vitro dissolution tests revealed over 85% drug release within 10 minutes, markedly faster than standard oral tablets, promoting efficient systemic absorption. Taste masking was accomplished using mannitol and peppermint flavor, enhancing palatability and patient satisfaction. Accelerated stability testing conducted over three months shown little alterations in hardness, disintegration, drug content, or dissolution behavior, confirming the formulation's robustness. In summary, the research demonstrated that the optimized sublingual tablets exhibit superior physicochemical properties, rapid disintegration, fast dissolution, stability, and enhanced patient acceptability. These qualities position sublingual tablets as an effective alternative for the prompt management of anxiety disorders..
Keywords	Sublingual tablet, Anxiety, Lorazepam, Sertraline, Buspirone, Novel formulation, Rapid disintegration
Field	Medical / Pharmacy
Published In	Volume 7, Issue 5, September-October 2025
Published On	2025-10-17
DOI	https://doi.org/10.36948/ijfmr.2025.v07i05.58043

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Formulation and Evaluation of Novel Sublingual Tablet for Anxiety

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