Casein Phosphopeptide–Amorphous Calcium Phosphate (CPP–ACP) in Pediatric Dentistry — A narrative Review

Author(s)	Dr. Rishabh Solanki, Dr. Nidhi Gupta, Dr. Natasha Gambhir
Country	India
Abstract	Casein phosphopeptide–amorphous calcium phosphate (CPP–ACP) is a milk-derived nanocomplex that stabilizes bioavailable calcium and phosphate ions next to tooth surfaces and promotes enamel remineralization. Over the past two decades, CPP–ACP formulations (e.g., GC Tooth Mousse, MI Paste) have been evaluated for caries prevention, management of white-spot lesions (WSLs), erosion prevention, and treatment adjuncts in special-needs pediatric populations. Clinical and laboratory evidence suggests beneficial effects, particularly as an adjunct to fluoride and for certain high-risk pediatric groups; however, heterogeneity in study design, small sample sizes, and variable delivery protocols limit definitive conclusions. Safety concerns are limited to milk-protein allergy. Future research should prioritize large randomized pediatric trials with standardized outcomes and head-to-head comparisons against modern fluoride regimens.
Keywords	Casein phosphopeptide, amorphous calcium phosphate, CPP–ACP, pediatric dentistry, remineralization, white spot lesions, dental caries prevention
Field	Medical / Pharmacy
Published In	Volume 7, Issue 5, September-October 2025
Published On	2025-10-30
DOI	https://doi.org/10.36948/ijfmr.2025.v07i05.58820

About IJFMR Fees & Payment Current Issue Publication Archive	Submit Research Paper Track Submission Status Publication Guidelines Publication Ethics Peer Review & Plagiarism	Join as a Reviewer Editors & Reviewers Reviewer Referral Program Get Reviewer Membership Certi.	Website/Journal Policies Usage Policy Content Policies Privacy Policy

Contact Us		+91-9687-828-838	editor@ijfmr.com

International Journal For Multidisciplinary Research