International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Methylation Profiling of TNBC Hub Genes Using UCSC Genome Browser: A Comparative Study Relevance to Reprogramming

Author(s) Ms. Shivi Sharma, Prashant Ankur Jain, Eliza Chakraborty
Country India
Abstract Using the UCSC genome browser, this study primarily examined the density of CpG Islands in each gene to investigate epigenetic changes, particularly methylation patterns or profile throughout the genome of TNBC genes. Here the analysis of 10 hub TNBC genes were study for the methylation profiling and additionally focused on its relevance of reprograming to these genes.
It can also analyze how certain genomic areas are conserved across species, which can reveal information about their functional significance. It also examines the existence of CpG islands, which could be connected to other regulatory elements or gene promoters. Examining the data on histone modifications to find possible promoters or enhancers. Genes such as AURKA, CDK1, EZH2, CCNA2, CTNNB1, MKI67, etc., are known cell cycle regulators, chromatin modifiers, and proliferation markers, many of which are overexpressed in cancer and stem cells, including induced pluripotent stem cells (iPSCs). These 10 genes are reprogramming-supportive genes and indirectly modulated or supported by Yamanaka factors. Their hypomethylation and expression patterns in these results indicate that the cellular environment in TNBC resembles a partially reprogrammed state, which may explain aggressive growth and plasticity — a useful insight for drug targeting strategies.
Keywords Keywords: TNBC, methylation profiling, CpG Island, Cancer Stem Cells, reprogramming.
Field Medical / Pharmacy
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-11-07
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.59030
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E-ISSN 2582-2160
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