International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 8, Issue 2 (March-April 2026) Submit your research before last 3 days of April to publish your research paper in the issue of March-April.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 8 Issue 2
March-April 2026

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Synthesis and Analysis of Theophylline co-crystals with various co-formers in molar ratios of 1:1 and 1:2.

Author(s) Mr. Rakshith Venkateshappa, Prof. Peter Nockemann
Country India
Abstract Theophylline co-crystals have been synthesised by pharmaceutical co-crystallisation with nicotinamide, succinic acid and glutaric acid in a stoichiometry of 1:1 and 2:1 molar ratios. This goal was achieved through the enhancement of physicochemical properties of poorly soluble BCS Class I drug like theophylline. So we use Solution-Based and Solid State Crystallisation)The morphological, bonding, and crystalline phases of the samples were characterised using POM, FTIR, and PXRD. Differential Scanning Calorimetry (DSC) and Single Crystal X-Ray Diffraction data were initially intended for both compounds, but this proved impossible due to a lack of instruments/access availability, as no suitable crystals could be grown in the case of AIBO3. The results obtained reveal a FTIR peak shift, morphological changes detected by POM, and differential PXRD patterns, which collectively provide evidence of the successful formation of a co-crystal, primarily in the case of nicotinamide and glutaric acid. Succinic acid gave weak or inconsistent results. This study presents a rapid and inexpensive method for co-crystal screening of theophylline systems.
Keywords Theophylline co-crystal formation, Drug–co-former interaction studies, Theophylline–nicotinamide complex, Theophylline–glutaric acid system, Theophylline–succinic acid co-crystal, Pharmaceutical solid-state modification.
Field Chemistry > Pharmacy
Published In Volume 7, Issue 5, September-October 2025
Published On 2025-10-31
DOI https://doi.org/10.36948/ijfmr.2025.v07i05.59265
View / Download PDF File

Share this



E-ISSN 2582-2160
CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

IJFMR DOI prefix is
10.36948/ijfmr

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 8 Isu 2Cover Page Vol 8 Isu 1Cover Page Vol 7 Isu 6

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJFMR
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us +91-9687-828-838 editor@ijfmr.com
Powered by Sky Research Publication and Journals