A Comprehensive Review on Biotechnological Advancement to Combat Dirraheal Disease

Author(s)	Rick Darshan Caussy, Anirban Mukherjee
Country	India
Abstract	Diarrheal disease in India—especially among children under five—persists despite WASH programs due to unsafe water, uneven sanitation, low ORS–zinc use, and antimicrobial resistance. We assess biotechnology solutions: CRISPR/mNGS diagnostics, novel vaccines, precision therapeutics, and community bioremediation/biosensors, with state-specific plans for Bihar, Uttar Pradesh, and West Bengal. BIDCP pilots cut severe hospitalizations, antibiotic use, and outbreak recurrence. Barriers include biosafety, regulation, infrastructure, acceptance, and uncertain long‑term cost-effectiveness. Embedding synthetic biology, precision public health, and digital platforms into health and WASH systems can accelerate equitable progress toward UHC and the SDGs. The current paper tries to do a comprehensive review on Biotechnological advancement to combat with the situation.
Keywords	Diarrheal Disease, Biotechnology, Molecular Diagnostics, Antimicrobial Resistance, Water, Sanitation, and Hygiene (WASH).
Field	Biology
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-11-15
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.59679

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