Thyroglossal duct cyst carcinoma metastasis in pleural effusion.

Author(s)	Dr. Natasha Modi, Dr. Kinjal Patel, Dr. Ritanshu Solanki, Dr. Avinash Munshi, Dr. Pranab Dey
Country	India
Abstract	Incidence of malignant pleural effusion (MPE) is about 500,000 new cases per year in the United States and Europe. The major cancers associated with direct, contiguous, or hematogenous spread to pleural involvement include those from lung, breast, and hematological malignancies and is associated with a poor prognosis. The most common anomaly in thyroid development is the thyroglossal duct cyst with a possibility of malignancy within remnants are 1 to 2%, the most common being papillary adenocarcinoma. Herein, we discuss a 64 years old male patient who presented to the emergency department complaining of shortness of breath associated with chest pain eventually diagnosed as thyroglossal duct cyst papillary carcinoma with metastatic deposits in pleural fluid. Distinguishing TGD associated carcinoma from primary pyramidal thyroid lobe cancer is important. It can be difficult to diagnose preoperatively, and preoperative US-guided FNA may be considered. Immunocytochemistry on cell block sections has a great potential in arriving at a diagnosis especially in cases with unknown primary.
Keywords	Thyroglossal duct cyst, Pleural effusion, Metastasis, TTF 1
Field	Medical / Pharmacy
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-11-09
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.60106

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