Green Synthesis of Novel Nitrogen-containing Scaffolds as Future Anticancer Agents

Author(s)	Prof. Dr. Harshita Sachdeva Sachdeva, Mr. Narsingh Khatik, Mr. Raju Lal Choudhary
Country	India
Abstract	New nitrogen containing cyclohexenone derivatives are synthesized by a clean, simple, and green method using graphite as a heterogeneous recyclable catalyst under grinding. Graphite can be readily separated from the reaction mixture and reused, offering a cost-effective approach for large-scale synthesis of bioactive molecules. The MTT cell cytotoxicity investigation results of the synthesized compounds indicate that novel 2-((4,4-dimethyl-2-oxo-6-(4-fluorophenylimino)cyclohexyl(substitutedphenyl)methyl)-3-hydroxy-5, 5-dimethylcyclohex-2-ene-1-one derivatives possess effective cytotoxic potential against NCI-H460 cell lines with the IC50 concentration of 81μg/ml, 60 μg/ml, 56 μg/ml, 30 μg/ml, and 41 μg/ml, respectively. Cisplatin with 15 μg/ml concentration was used as a standard control for the study. Overall, compounds demonstrated adequate cytotoxicity against lung cancer cell lines and may act as lead molecules for the development of potential anti cancer drugs.
Keywords	Graphite; mechanochemistry; cyclohexenone; nitrogen-scaffolds; NCI-H460 cell lines.
Field	Chemistry > Pharmacy
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-11-12
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.60153

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