International Journal For Multidisciplinary Research

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Therapeutic Use of Ibuprofen and Paracetamol in Sickle Cell Anemia Pain Crisis

Author(s) Ms. Savanth Uthkarsha, Ms. Kethe Shravani, Ms. Lakavath Kalynai, Ms. Erroji Vyshnavi, Dr. K. Purnachander, V. Raj Kumar
Country India
Abstract SCD is a genetic disorder caused by a mutation in the beta-globin gene, leading to the production of HbS, which polymerizes in conditions of low oxygen tension and leads to hemolytic anemia, sickling of red blood cells, vaso-occlusion, and increased susceptibility to infection. Epidemiology in India, using methods such as high-performance liquid chromatography and electrophoresis, shows the variability in the severity of the disease, modulated by population genetics and coexisting hemoglobinopathies. Management includes hydroxyurea, red blood cell transfusion, stem cell transplantation, newer gene therapy, and symptomatic pain management with paracetamol or NSAIDs like ibuprofen.This prospective study will include patients who are 18 years of age or older and who visit the sickle cell department at Prathima Institute of Medical Sciences, Nagunoor, Karimnagar. Patients with thalassemia and those over the age of 18 will not be accepted. Out of the 230 sickle cell patients analyzed, O+ was the most prevalent blood group (46.08%), with 59.56% homozygous and 40.43% heterozygous DNA types. For as long as eight hours, ibuprofen and paracetamol tablets effectively and continuously relieved symptoms.
Keywords Sickle cell anaemia, Paracetamol, Ibuprofen.
Field Medical / Pharmacy
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-11-11
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.60327
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