Therapeutic Plasma Exchange In Steroid Refractory  Autoimmune Encephalitis - A Case Report

Author(s)	Dr. Kuralarasi Priyadarshini, Dr. Gopinathan Mathiyazhagan, Dr. Ingersal Natarajan
Country	India
Abstract	A 63-year-old female with a known case of diabetes mellitus, hypertension, primary Sjögren's syndrome, carcinoma left breast on immunotherapy atezolizumab, presented with confusion, drowsiness (GCS E3VTM4), fever and respiratory distress. Neuroimaging studies did not reveal any structural abnormalities, and the paraneoplastic panel of neuronal antibodies were tested negative. The patient was clinically diagnosed to be a case of AE (Autoimmune Encephalitis). Due to persistent encephalopathy and unresponsiveness to steroid therapy, she was scheduled for a therapeutic plasma exchange (TPE), and after six sessions patient showed significant clinical improvement. This case report emphasizes the importance of TPE along with immunotherapy in the management of steroid-unresponsive Autoimmune Encephalopathy.
Keywords	autoimmune encephalitis, malignancy, plasma exchange
Field	Medical / Pharmacy
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-11-13
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.60554

About IJFMR Fees & Payment Current Issue Publication Archive	Submit Research Paper Track Submission Status Publication Guidelines Publication Ethics Peer Review & Plagiarism	Join as a Reviewer Editors & Reviewers Reviewer Referral Program Get Reviewer Membership Certi.	Website/Journal Policies Usage Policy Content Policies Privacy Policy

Contact Us		+91-9687-828-838	editor@ijfmr.com

International Journal For Multidisciplinary Research