International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Cytotoxic and Apoptotic Effects of Annona muricata: A Review of In Vitro Anticancer Studies

Author(s) Ms. Swathi Rani SampathiRao, Prof. SPD Ponamgi, Dr. KantiPriya Kondala, Prof. Sujatha Peela
Country India
Abstract Abstract:
Annona muricata L. (Annonaceae), known as soursop or graviola, is a tropical plant traditionally used to manage various ailments, including cancer. Numerous in vitro studies have demonstrated its potent cytotoxic and pro-apoptotic effects against diverse human cancer cell lines. This review summarizes current in vitro evidence on the anticancer properties of A. muricata, emphasizing its cellular and molecular mechanisms. Phytochemical analyses identify annonaceous acetogenins, alkaloids, and phenolic compounds as key constituents responsible for selective cytotoxicity. Mechanistic studies reveal that A. muricata induces apoptosis through mitochondrial membrane depolarization, reactive oxygen species (ROS) generation, caspase activation, and modulation of apoptosis-related genes such as Bax, Bcl-2, and p53. While results consistently support its anticancer potential, variations in extraction methods, dosages, and cell models limit direct comparison across studies. Overall, A. muricata shows promising in vitro antitumor activity, warranting standardized and mechanistically driven research to enable future clinical validation.
Keywords Annona muricata, apoptosis, cytotoxicity, in vitro, anticancer activity, acetogenins.
Field Biology
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-11-16
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.60602
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