In Silico Molecular Docking Study For Binding Affinity Of Guduchi (Tinospora Cordifolia Willd) On Angiotensin II Type 1 Receptor (AT1R) & PPAR-γ With Special Reference To Diabetic Nephropathy.

Author(s)	Dr. Rajshree Dinesh Gavand, Dr. Preeti Rajesh Yadav, Dr. Oshin Rajeev
Country	India
Abstract	Diabetic nephropathy (DN) is a major complication of diabetes mellitus, characterized by vasoconstriction & profibrotic effects of Ang II and renal inflammation, insulin sensitivity such as PPAR-γ and Angiotensin II type 1 receptor (AT1R). Current therapeutic strategies are often limited by side effects and incomplete efficacy, highlighting the need for safer, natural alternatives. Guduchi (Tinospora cordifolia willd), a traditional medicinal plant, possesses potent anti-inflammatory, antioxidant, and antidiabetic properties, making it a promising candidate for targeting molecular pathways involved in Diabetic Nephropathy. The present in silico study aims to evaluate the molecular docking interactions and binding affinity of Phytoconstituents from Guduchi (Tinospora cordifolia willd) with key target proteins Angiotensin II type 1 receptor (AT1R) & PPAR-γ, which play a central role in the pathogenesis of diabetic nephropathy.
Keywords	Diabetic nepropathy, Angiotensin II type 1 receptor (AT1R), PPAR-γ, Guduchi,molecular docking, in silico study.
Field	Medical / Pharmacy
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-11-19
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.60872

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