Solid Dispersion Technique: an Emerging Approach to Enhance Solubility and Bioavailability of Poorly Water-soluble Drugs

Author(s)	Mr. ARYAN DEEPAK ZEND, Mr. SUSHANT SHANKAR ZOPE, Mr. VAIBHAV RAVINDRA THAKARE, Prof. ADITI SHIRISH MARATHE
Country	India
Abstract	Improving oral bioavailability of medicine those given as solid dosage forms remains a challenge for the formulation of scientists because of solubility problems. The dissolution rate can be the rate-limiting process within the absorption of a drug from a solid dosage sort of relatively insoluble drug. The historical background of solid dispersion technology, has limitations, classification, and various preparation techniques with its advantages and drawbacks. This review also discusses the recent advances within the field of solid dispersion technology. Supported the prevailing results and authors reflection, this review gives rise to reasoning and suggested choices of carrier or matrix and solid dispersion procedure.
Keywords	Solid dispersion, Solubility enhancement, Bioavailability, Poorly water-soluble drugs, Amorphous form, Hydrophilic carriers. Dissolutions , Matrix , Poorly soluble drug .
Field	Physical Science
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-11-19
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.60932

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