International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 7 Issue 6
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Formulation and Evaluation of Extended-Release Tablets of an Anti Ischemic Agent Trimetazidine HCL

Author(s) Ms. Afiya Siddiqui, Prof. Dr. Syed Areefullah Hussainy, Prof. Dr. Abdul Sayeed
Country India
Abstract The present study focuses on the Formulation and Evaluation of Extended-Release Tablets of Trimetazidine Hcl, an anti-ischemic agent used in the management of angina pectoris. The primary objective was to develop a sustained-release dosage form to maintain consistent plasma drug levels, reduce dosing frequency, and improve patient compliance. Various formulations were prepared using suitable polymers and evaluated for both pre-compression and post-compression parameters, including flow properties, hardness, friability, weight variation, drug content, and in vitro drug release. All evaluated parameters were found to be within the acceptable limits as per IP standards.
Among the formulations, F2 was identified as the optimized batch, demonstrating a desirable extended drug release profile with 99.32% cumulative drug release over 12 hours. The drug release followed controlled-release kinetics, indicating the effectiveness of the matrix system used. This study concludes that the optimized formulation of Trimetazidine HCl extended-release tablets offers a promising approach for sustained therapy in ischemic conditions, ensuring better therapeutic outcomes and improved patient adherence.
Keywords Extended-Release Tablets of Trimetazidine Hcl , Angina pectoris, HPMC K100M.
Field Medical / Pharmacy
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-11-22
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.61260
Short DOI https://doi.org/hbb77s
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