Role of Gut Microbiota Modulation through Probiotics in Managing Cardiovascular Risk: An Indian Regional Perspective

Author(s)	Ms. Minakshi Kumari, Prof. Dr. Dr. Vijay Kant Pandey
Country	India
Abstract	Cardiovascular diseases are responsible for 28% of all deaths in India, making it one of the leading causes of mortality. The gut microbiota has a profound impact on heart health through mechanisms such as lipid metabolism, inflammation, and metabolite production, including trimethylamine N-oxide. In this review, we consider the potential of probiotic exposure as an opportunity to manipulate the gut microbiota and reduce cardiovascular risk factors that are specific or unique to the Indian population. We focus on special consideration for Indian-specific dietary patterns and genetic predisposition to CVDs and other environmental factors that set them apart from other populations. Here, we review the current understanding of the gut-heart axis, clinical trials of probiotic supplementation aimed at reducing CVD risk, and the use of traditional Indian fermented foods as a probiotic source. It is essential to conduct more population-specific research as the Indian population has more variations in their makeup of microbiomes and cardiovascular risk profiles.
Keywords	Gut microbiota; probiotics; cardiovascular disease; TMAO; fermented foods
Field	Biology > Medical / Physiology
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-11-22
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.61376
Short DOI	https://doi.org/hbb763

About IJFMR Fees & Payment Current Issue Publication Archive	Submit Research Paper Track Submission Status Publication Guidelines Publication Ethics Peer Review & Plagiarism	Join as a Reviewer Editors & Reviewers Reviewer Referral Program Get Reviewer Membership Certi.	Website/Journal Policies Usage Policy Content Policies Privacy Policy

Contact Us		+91-9687-828-838	editor@ijfmr.com

International Journal For Multidisciplinary Research