International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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In vitro Evaluation of Antioxidant and Anticancer Effects of Viscum album Mother Tincture on Breast Carcinoma Cell Lines (MCF-7)

Author(s) Dr. Iswarya Sangameswaran, Dr D. Dilipkumar, Dr. Ginu D. Mohan, DrSangameswaran Balakrishnan
Country India
Abstract Breast cancer remains a leading cause of morbidity and mortality among women worldwide. Despite advancements in chemotherapy and radiotherapy, the associated side effects, resistance, and diminished quality of life have necessitated alternative therapeutic approaches. Viscum album (European mistletoe) is known for its antioxidant, immunomodulatory, and cytotoxic properties attributed to bioactive components such as lectins, viscotoxins, and phenolic compounds. This study evaluates the antioxidant and anticancer effects of Viscum album mother tincture on MCF-7 human breast carcinoma cell lines. The antioxidant activity was determined using DPPH and reducing power assays, while cytotoxicity was assessed through MTT assay. The mother tincture exhibited significant dose-dependent free radical scavenging and cytotoxic activity, with an IC₅₀ value of approximately 54 µg/mL (DPPH) and 65 µg/mL (MTT), comparable to the standard drug doxorubicin. These findings suggest that Viscum album mother tincture possesses potent antioxidant and anticancer properties, indicating its potential role as a complementary therapy in breast cancer management.
Keywords Viscum album, MCF-7, antioxidant, cytotoxicity, MTT assay, breast carcinoma.
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-11-28
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.61779
Short DOI https://doi.org/hbdr7g
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