International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 7 Issue 6
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Immune Conversations Gone Wrong: Crosstalk Mechanisms Driving Alzheimer’s, Parkinson’s, and Depression

Author(s) Ms. Tiyasha Mishra, Ms. Ahana Chakraborty
Country India
Abstract Major depressive disorder (MDD), Parkinson's disease (PD), and Alzheimer's disease (AD) are examples of neurodegenerative and neuropsychiatric illnesses that have historically been seen through different pathological lenses. However, new research from 2018 to 2025 indicates that these disorders share a similar immunological foundation, characterized by an inappropriate interaction between the peripheral and central immune systems. Chronic neuroinflammation and synaptic failure result from this immunological dysregulation, which is caused by astrocytic reactivity, microglial priming, cytokine imbalance, and disruption of the gut-brain axis. The concept of "immune conversations gone wrong" underscores how neuroimmune communication, which is beneficial during homeostasis, becomes detrimental during illness. This review illustrates the interaction between innate and adaptive immune signaling networks in AD, PD, and MDD, incorporating recent multi-omics, neuroimaging, and clinical research findings. It highlights converging pathways such as NF-κB activation and interferon-mediated responses. Gaining insight into these common immune circuits could lead to the discovery of new treatment targets aimed at restoring equilibrium in neuroimmune interactions.
Keywords MDD, AD,PD, Neuroinflammation
Field Biology > Genetics / Molecular
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-11-28
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.61857
Short DOI https://doi.org/hbdsrr
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