International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 7 Issue 6
November-December 2025

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Formulation and Evaluation of Oxyphenbutazone loaded transdermal patches

Author(s) Ms. Sana Fatima, Dr. Syed Areefullah Hussainy, Dr. Abdul Sayeed
Country India
Abstract The present study focuses on the formulation and evaluation of oxyphenbutazone-loaded transdermal patches intended to provide sustained drug delivery and enhance patient compliance. Oxyphenbutazone, a non-steroidal anti-inflammatory drug (NSAID), is associated with gastrointestinal side effects when administered orally; hence, transdermal delivery offers a promising alternative. The patches were prepared using the solvent casting technique with various polymers such as HPMC, PVA and SCMC in different ratios. The formulated patches were evaluated for physicochemical parameters including thickness, weight variation, folding endurance, surface pH, moisture content, moisture uptake, drug content, and in vitro drug release. Among the formulations, the optimized patch exhibited desirable properties and sustained drug release for up to 12 hours. The drug release kinetics followed controlled release behavior, indicating the potential of the developed patch as an effective transdermal drug delivery system for oxyphenbutazone. This approach may reduce the frequency of dosing and minimize systemic side effects, thereby improving overall therapeutic outcomes
Keywords Formulation of Oxyphenbutazone-Loaded Transdermal Patches, HPMC, PVA.
Field Medical / Pharmacy
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-11-27
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.61881
Short DOI https://doi.org/hbdsrg
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