Synthesis, Characterization and Antimicrobial Activity of Oxadiazine Derivatives

Author(s)	Mr. Mayurkumar Manchharam Patel, Maulikkumar Arvindbhai Patel, Mohyuddin Abdulbhai Maradiya, Rameshbhai Narsinhbhai Patel
Country	India
Abstract	4-(1,3-dioxoisoindolin-2-yl)benzo hydrazide (1) reacted with KCNS yielded 2-(4-(1,3-dioxoisoindolin-2-yl)benzoyl) hydrazine carbothioamide (2), which on reacted with H2SO4 / NH3 yielded 2-(4-(5-amino-1,3,4-thiadiazol-2-yl)phenyl)isoindoline-1,3-dione(3). The compound (3) reacted with various substituted aldehyde(4a-g) derivatives yielded 2-(4-(5-(Arylideneamino)-1,3,4-thiadiazol-2-yl)phenyl)isoindoline-1,3-dione (5a-g), they further reacted with benzoyl isothiocyanate (6) yielded 2-(4-(5-(2-aryl-6-phenyl-4-thioxo-2H-1,3,5-oxadiazin-3(4H)-yl)-1,3,4-thiadiazol-2-yl)phenyl)isoindoline-1,3-dione (7a-g). All the novel compounds are characterized by elemental analysis a well as spectral study and they confirmed the predicted structure. Antimicrobial Activity of all synthesised compounds are also carried out. All they show moderate to good antimicrobial activity.
Keywords	Hydrazide, Schiff’s base, Oxadiazine, Elemental analysis, Spectral study and Antimicrobial Activity
Field	Chemistry
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-12-02
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.61928
Short DOI	https://doi.org/hbdsq5

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