Synthesis, Characterization and Antimicrobial Activity of Thiazolidine Derivative

Author(s)	Mr. Maulikkumar Sathavara, Mr. Mayurkumar Patel, Mr. Parth Barot, Dr. Rameshbhai Patel
Country	India
Abstract	Sulfadiazine (1) on reaction with chloroacetyl chloride yielded 2-chloro-N-(4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)acetamide (2), which when reacted with NH4SCN yielded 4-((4-oxo thiazolidin-2-ylidene)amino)-N-(pyrimidin-2-yl)benzenesulfonamide (3), compound 3 on reacted with aryl diazonium salt (4a-g) yielded 4-(4-oxo-5-(2-arylhydrazono)thiazolidin-2-ylidene)amino-N-(pyrimidin-2-yl)benzenesulfonamide (5a-g). All the novel compounds were characterized by elemental analysis a well as spectral study and confirmed the predicted structure. Antimicrobial Activity of all synthesized compounds was also carried out. All the compound showed moderate to good antimicrobial activity.
Keywords	Sulfadiazine, Thiazolidine, Elemental analysis, Spectral study and Antimicrobial Activity.
Field	Chemistry
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-12-14
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.61982

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