From Efficacy to Safety: A Pharmacovigilance Review of Phenformin

Author(s)	Bhakti Atmaram Chitrak, Umme Ruman Shaikh
Country	India
Abstract	Phenformin is a biguanide antidiabetic agent historically used in the management of type 2 diabetes mellitus. It demonstrates potent glucose-lowering efficacy by inhibiting hepatic gluconeogenesis and enhancing peripheral glucose uptake. Despite its effectiveness, clinical use of Phenformin declined due to the risk of lactic acidosis, a rare but life-threatening adverse drug reaction. Pharmacovigilance plays a critical role in identifying, monitoring, and preventing such adverse effects to ensure patient safety. This review provides a comprehensive analysis of Phenformin’s pharmacological profile, therapeutic efficacy, associated adverse effects, risk factors, and the pharmacovigilance measures implemented to mitigate risks. Clinical evidence, regulatory perspectives, and lessons learned from historical data are discussed to highlight the importance of vigilant drug safety monitoring in modern clinical practice.
Field	Medical / Pharmacy
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-11-27
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.62143
Short DOI	https://doi.org/hbdsmt

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