International Journal For Multidisciplinary Research
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Volume 7 Issue 6
November-December 2025
Indexing Partners
Antibiotic Resistance and Pharmacovigilance Issues Related to Cefixime Use in India
| Author(s) | Pranali Prakash Borse, Syeda Afifa |
|---|---|
| Country | India |
| Abstract | Cefixime, an oral third-generation cephalosporin, is widely used in India for the management of respiratory, urinary, and enteric bacterial infections. Its extensive availability in both urban and rural markets, combined with frequent empirical prescribing, has resulted in increasing antimicrobial resistance across several pathogenic species. In recent years, resistance to Cefixime has emerged as a significant clinical and public-health concern, particularly among Escherichia coli, Klebsiella pneumoniae, Neisseria gonorrhoeae, and Salmonella typhi. This review evaluates patterns of Cefixime resistance in India and explores contributing factors such as irrational antibiotic use, self-medication, over-the-counter accessibility, and inappropriate treatment durations. Additionally, the paper highlights pharmacovigilance gaps in monitoring adverse drug reactions and therapeutic failures, both of which are essential for detecting early resistance signals. Strengthening pharmacovigilance reporting, implementing antibiotic-stewardship programs, and promoting rational prescribing practices are critical steps for controlling the rise of Cefixime resistance in India. |
| Keywords | Cefixime, Antibiotic resistance, Pharmacovigilance, India, ADR monitoring, ESBL, AMR, Post-marketing surveillance. |
| Field | Medical / Pharmacy |
| Published In | Volume 7, Issue 6, November-December 2025 |
| Published On | 2025-11-27 |
| DOI | https://doi.org/10.36948/ijfmr.2025.v07i06.62150 |
| Short DOI | https://doi.org/hbdsmn |
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