Cisplatin in Cancer Therapy: Pharmacology, Toxicity, and Nanotechnology Based Enhancements

Author(s)	Sanjivani Gawali, Prof. Umme Roman Shaikh
Country	India
Abstract	Cisplatin (cis-diamminedichloroplatinum(II)) is a platinum-based chemotherapy cornerstone used since the 1970s for testicular, ovarian, bladder, head & neck, lung and other solid tumours. Its clinical utility is limited by dose-limiting toxicities (notably nephrotoxicity, ototoxicity and neurotoxicity) and by the frequent development of tumour resistance. This review summarises cisplatin’s chemistry and pharmacology, molecular mechanism of action, main toxicities and mechanisms of resistance, and recent strategies — including combination therapies and drug-delivery/nanotechnology approaches — aimed at improving therapeutic index and overcoming resistance.
Field	Medical / Pharmacy
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-11-27
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.62151
Short DOI	https://doi.org/hbdsmm

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International Journal For Multidisciplinary Research