International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

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Volume 7 Issue 6
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Neuroplasticity and Neural Regeneration: Integrating Physiotherapy with Cellular and Electromagnetic Stimulation Therapies for Enhanced Neural Recovery

Author(s) Dr. Arpita Govind Rathod, Prof. Dr. Mahendra Shende
Country India
Abstract Neuroplasticity and neural regeneration are central mechanisms underlying recovery following central or peripheral nervous system injury. Recent advances in rehabilitation emphasize combining physiotherapy with cellular regeneration therapies and electromagnetic neuromodulation to maximize recovery. This review synthesizes evidence from 2015–2025 on integrating activity-based physiotherapy, stem-cell therapy, Schwann-cell transplantation, exosome-mediated repair, functional electrical stimulation (FES), neuromuscular electrical stimulation (NMES), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS). Physiotherapy serves as the primary driver of activity-dependent plasticity, while biological and neuromodulatory therapies accelerate synaptic reorganization, axonal regeneration, and cortical remapping. Integrated approaches consistently demonstrate superior outcomes in gait recovery, upper-limb dexterity, sensory restoration, and ADL performance in stroke, spinal cord injury (SCI), traumatic brain injury (TBI), and peripheral nerve lesions. This article presents a comprehensive review, clinical implications, and a proposed multimodal model for neuroregenerative rehabilitation.
Keywords Neuroplasticity, Neural regeneration, Stem-Cell Therapy, Mesenchymal Stem Cells, Schwann-Cell Transplantation, Exosomes, rTMS, tDCS, FES, Physiotherapy, Activity-Based Therapy, Neurorehabilitation
Field Medical / Pharmacy
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-11-30
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.62190
Short DOI https://doi.org/hbdsk2
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