Synergistic Antibacterial Efficacy of Doxycycline and Magnesium Oxide-Loaded Nanoparticles Against Salmonella typhi

Author(s)	Mr. Sanjay Kushwaha, Mr. Anshul Chaubey, Mr. Nirbhik Karan, Mr. Dev Sharan Chaturvedi
Country	India
Abstract	In this study, the combination of doxycycline and MgO nanoparticles was investigated for its synergistic antibacterial activity against Salmonella Typhi. Various formulations with different concentrations of doxycycline (50 µg/mL, 100 µg/mL, and 200 µg/mL) and MgO nanoparticles (0.1 mg/mL, 0.5 mg/mL, and 1 mg/mL) were prepared. The combination of 100 µg/mL doxycycline + 1 mg/mL MgO was selected for further analysis based on its strong antibacterial activity as indicated by the zone of inhibition (22 mm), MIC (25 µg/mL), and MBC (50 µg/mL) values. The Fractional Inhibitory Concentration Index (FICI) for this combination was calculated to be 0.4, indicating a synergistic effect.
Keywords	Synergistic, Salmonella typhi, Magnesium Oxide-Loaded, Bacterium, multidrug-resistant, extensively drug-resistant, typhoid conjugate vaccine, antimicrobial resistance Extended- spectrum beta- lactamases (ESBL)
Field	Medical / Pharmacy
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-12-04
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.62433

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