Recent Advancement in Hybrid and Stimuli Responsive Hydrogels for Chronic Wound Healing

Author(s)	Dr. Rashmi Kumari
Country	India
Abstract	Chronic wounds — including diabetic ulcers, pressure sores, venous leg ulcers and non healing surgical or trauma wounds — pose a persistent global health challenge due to their complex pathophysiology characterized by persistent inflammation, oxidative stress, elevated protease activity, microbial biofilms, impaired angiogenesis and extracellular matrix (ECM) degradation. Conventional dressings often fail to address the dynamic and multifactorial microenvironment of such wounds. Hybrid and stimuli responsive hydrogels have recently emerged as promising multifunctional platforms: by combining natural and synthetic polymers, nanomaterials and bioactive agents, these “smart” dressings offer mechanical robustness, controlled therapeutic release, redox regulation, antimicrobial activity and environment responsiveness. This review examines the design principles, biological functions and recent advances in such hydrogels, summarizes in vitro and in vivo evidence, discusses translational challenges and outlines future directions toward clinical application.
Keywords	Chronic wounds, hybrid hydrogel, stimuli-responsive, thermoresponsive, nanozyme, antimicrobial, ROS scavenging, angiogenesis, wound healing.
Field	Chemistry
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-12-12
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.62941

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