International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Optimisation and Evaluation of Opthalmic Gel containing Solid Nanoparticles loaded with Ciprofloxacin

Author(s) Ms. Nidhi Rajput
Country India
Abstract Delivering drugs to the eye remains difficult because numerous anatomical and physiological defenses limit how long therapeutic agents stay on the ocular surface and how effectively they pass through surrounding tissues. Ciprofloxacin hydrochloride, a commonly prescribed antibiotic for bacterial infections of the eye, is an example of a drug whose effectiveness is reduced when administered in traditional drop formulations, largely due to rapid clearance and limited absorption.
Recent developments in nanotechnology are opening new possibilities for overcoming these constraints. In particular, combining solid lipid nanoparticles (SLNs) with in-situ gelling systems has emerged as a promising strategy for extending ocular residence time and improving drug penetration. SLNs can protect the drug, regulate its release, and enhance its interaction with the corneal surface, while in-situ gels transform into a more viscous form upon contact with the eye’s natural environment, helping the formulation remain in place longer.
Embedding ciprofloxacin-loaded SLNs within such a gel formulation may increase the drug’s therapeutic impact, allow for fewer daily administrations, and potentially improve patient adherence to treatment. This integrated delivery platform represents an innovative direction for managing bacterial ocular infections and may offer meaningful advantages for future ocular drug-delivery research.
Field Medical / Pharmacy
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-12-09
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.62981
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E-ISSN 2582-2160
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