Optimisation and Evaluation Of Topical Gel containing Solid Nanoparticles loaded with Ketoconazole

Author(s)	Mr. Prashant Sharma
Country	India
Abstract	Superficial fungal infections remain highly prevalent and often require extended treatment before full resolution is achieved. Ketoconazole, an imidazole-class antifungal, demonstrates strong activity against dermatophytes and yeasts; however, its poor water solubility and limited ability to penetrate skin restrict the effectiveness of conventional topical formulations. These shortcomings often result in inconsistent therapeutic outcomes. Solid lipid nanoparticles (SLNs) have gained attention as a modern drug-delivery technology capable of enhancing solubility, modulating drug release, and improving dermal uptake of lipophilic agents. This review discusses the pharmacological relevance of ketoconazole, the drawbacks of traditional topical systems, and the formulation considerations, characterization methods, and therapeutic promise of SLN-based ketoconazole gels as an advanced approach for treating superficial mycoses.
Field	Medical / Pharmacy
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-12-09
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.62985

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