International Journal For Multidisciplinary Research

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Evaluation of the Anti-ulcer Activity of a Polyherbal Formulation in Experimentally Induced Gastric Ulcers in Rats

Author(s) Mr. Ajay Dhananjay Fadtare, Dr. Suresh G. killedar
Country India
Abstract Gastric ulcer is a multifactorial gastrointestinal disorder resulting from an imbalance between aggressive factors such as gastric acid, pepsin, non-steroidal anti-inflammatory drugs (NSAIDs), alcohol, stress, and reactive oxygen species, and protective mechanisms including mucus secretion, bicarbonate, prostaglandins, antioxidant defenses, and epithelial regeneration. Conventional anti-ulcer therapies, including proton pump inhibitors, H₂-receptor antagonists, and antacids, though effective, are often associated with adverse effects such as hypergastrinemia, renal complications, osteoporosis, and ulcer recurrence, particularly upon long-term use. Polyherbal formulations, rooted in traditional medicinal systems like Ayurveda, Siddha, and Unani, combine multiple medicinal plants to provide a synergistic and multi-targeted therapeutic approach, addressing various ulcerogenic pathways simultaneously. Experimental studies using rat models, such as ethanol-induced, aspirin-induced, pylorus ligation-induced, and stress-induced gastric ulcers, have demonstrated that polyherbal formulations significantly reduce ulcer index, decrease gastric acidity, enhance mucus production, restore antioxidant status, and protect against inflammatory and histopathological damage. The pharmacological effects are largely attributed to bioactive phytoconstituents such as flavonoids, tannins, saponins, alkaloids, and phenolic compounds. Collectively, these findings highlight the therapeutic potential of polyherbal formulations as effective, safe, and multi-mechanistic agents for the management and prevention of gastric ulcers.
Keywords Gastric ulcer; Polyherbal formulation; Anti-ulcer activity; Gastroprotection; Experimental rat models
Field Medical / Pharmacy
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-12-30
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.63802
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