International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Exploring Organic Compounds as Anti-Viral Agents

Author(s) Mrs Suman Kumari
Country India
Abstract Organic compounds, both natural and synthetic, have gained significant importance as promising antiviral agents due to their structural versatility, chemical diversity, and wide range of biological activities. Natural organic molecules including flavonoids, polyphenols, alkaloids, terpenoids, peptides, and polysaccharides derived from plants and marine organisms have demonstrated potent antiviral effects against viruses such as Influenza virus, SARS-CoV-2, HIV, Dengue virus, Zika virus, Chikungunya virus and Mayaro virus. Their antiviral action is attributed to multiple mechanisms including inhibition of viral entry, suppression of viral replication and transcription, interference with viral protein synthesis, and modulation of host immune responses. Marine natural products, in particular, display exceptional antiviral activity owing to their unique structures, high bioactivity, and chemical novelty, with compounds such as fucoidan, avarol, kainic acid, and caulerpin showing notable efficacy in preclinical studies. Synthetic organic compounds including heterocycles, quinones, and nucleoside analogs also contribute significantly to antiviral drug development by offering improved stability, enhanced target specificity, and lower toxicity. Despite promising advances, limitations involving compound stability, low bioavailability, complex extraction and purification, and lack of extensive clinical validation continue to restrict large-scale applications. The continuous emergence of viral pandemics highlights the urgent need for the discovery, optimization, and development of effective organic antiviral agents. This review presents an integrated overview of natural and synthetic organic molecules with antiviral activities, their mechanisms of action, challenges in drug development, and future perspectives for therapeutic applications.
Keywords Organic compounds, Antiviral agents, Medicinal plants, Marine natural products, Synthetic antivirals, SARS-CoV-2, Influenza, HIV, Arboviruses.
Field Chemistry
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-12-26
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.64074
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E-ISSN 2582-2160
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