International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

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Adaptive Metabolic Awakening of "Staphylococcus aureus" Persisters: Mechanisms and Therapeutic Implications

Author(s) Devjit Datta
Country India
Abstract Staphylococcus aureus is a major human pathogen responsible for acute and chronic infections, including endocarditis, osteomyelitis, and device-associated biofilm infections. A key contributor to treatment failure and infection relapse is the formation of persister cells—phenotypic variants that survive lethal antibiotic exposure without acquiring genetic resistance. Historically, persisters were considered metabolically dormant; however, accumulating evidence demonstrates that S. aureus persisters retain low-level or adaptable metabolic activity that can be therapeutically exploited. This review synthesizes current knowledge on the metabolic states of S. aureus persisters and explores strategies aimed at inducing metabolic reactivation (“awakening”) to restore antibiotic susceptibility. We discuss regulatory pathways governing persistence, metabolic heterogeneity within persister populations, and emerging therapeutic approaches such as metabolite-enabled antibiotic potentiation, respiration modulation, and proteostasis disruption. Finally, we highlight experimental challenges and future directions required to translate metabolic awakening strategies into clinically effective anti-persister therapies.
Keywords Staphylococcus aureus; persister cells; metabolic reactivation; antibiotic tolerance; biofilms; metabolic heterogeneity; anti-persister therapy
Field Medical / Pharmacy
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-12-26
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.64182
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E-ISSN 2582-2160
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