International Journal For Multidisciplinary Research

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Prevalence Of Thyroid Dysfunction in Patients with Chronic Kidney Disease – A Cross-Sectional Study

Author(s) Dr. Nishant Deb, Dr. Alokananda Purkayastha, Dr. Biswadeep Choudhury
Country India
Abstract Abstract
Background: Chronic Kidney Disease (CKD) affects multiple organ systems including the endocrine axis. Thyroid dysfunction, particularly hypothyroidism, is common among CKD patients due to alterations in thyroid hormone metabolism and excretion. Chronic kidney disease (CKD) is characterized by a low T3 syndrome which is now considered a part of an atypical nonthyroidal illness.
Objective: To assess the prevalence of thyroid dysfunction in adult patients with chronic kidney disease and explore associations between thyroid hormone levels and renal function parameters.
Methods: A hospital-based cross-sectional observational study was conducted on 50 adult CKD patients. Thyroid function tests (TSH, FT3, FT4) and serum creatinine were measured. Statistical analysis included descriptive statistics, correlation analysis, and chi-square tests.
Results: The mean age was 58.20 ± 14.73 years with 54% males. Overall thyroid dysfunction prevalence was 56%, with subclinical hypothyroidism being most common (40%), followed by overt hypothyroidism (8%), low T3 syndrome (4%), and subclinical hyperthyroidism (4%). Mean TSH was 7.47 ± 20.93 mIU/L, FT4 was 1.36 ± 0.60 ng/dL, and FT3 was 2.87 ± 0.72 pg/mL. A statistically significant association was found between CKD stage and thyroid dysfunction (χ² = 6.30, p = 0.043). However, no significant correlation was observed between individual thyroid parameters and serum creatinine levels.
Conclusion: Thyroid dysfunction, particularly subclinical hypothyroidism, is highly prevalent in CKD patients. Regular thyroid screening should be considered in CKD management protocols.
Keywords Chronic kidney disease, thyroid dysfunction, subclinical hypothyroidism, TSH, CKD staging
Field Biology > Medical / Physiology
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-12-30
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.65065
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