International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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The Role of IL-6 level with IR in type II diabetes mellitus: A brief study

Author(s) Shagun Singh, Nidhi Attari, Prof. Dr. Krishna Gopal Parihar, Dr. Mukesh Kumar Gupta
Country India
Abstract OBJECTIVE; IL-6 (Interleukin-6) is a key pro-inflammatory cytokine recognized for its role in the development and progression of insulin resistance (IR) in Type 2 Diabetes Mellitus (T2DM) in the body. Elevated IL-6. IL-6 interferes with insulin signaling by promoting hepatic gluconeogenesis, altering adipocyte function, and activating inflammatory pathways such as JAK/STAT and NF-κB. This study is mainly focusing on the possible role of proinflammatory markers interleukin-6 along with insulin resistance in type -2 diabetic subjects.

MATERIAL AND METHODS ; The study was conducted in 200 human subjects out of whom 100 were normal healthy individuals (group I) and 100 were type 2 diabetic subjects with complications (group II).

RESULTS; Showing the comparative changes of immunological and insulin resistance (HOMA-IR) parameters in group I healthy male and female subjects and group II diabetic male and female subjects. IL-6,(HOMA-IR) were highly significant at (P<0.001).

CONCLUSION; Outcome of this study showed that IL-6 plays an important role in insulin resistance. The adipokines produced by adipocytes or by adipose tissue infiltrating macrophages, are able to induce a low grade inflammation state that could play a central role in obesity and type-2 diabetes related insulin resistance.
Keywords IL-6, Diabetes mellitus, insulin resistance, Proinflammatory cytokines
Field Biology > Bio + Chemistry
Published In Volume 8, Issue 1, January-February 2026
Published On 2026-01-23
DOI https://doi.org/10.36948/ijfmr.2026.v08i01.65878
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