International Journal For Multidisciplinary Research

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Effect of Mentha piperita and Aloe vera in Estrous cycle on Estradiol Valerate induced Polycystic ovarian syndrome in mice (Mus musculus)

Author(s) Sipu Kumari, Rajesh Kumar, Dharmshila Kumari
Country India
Abstract Background:- Infertility due to polycystic ovarian syndrome (PCOS) is a worldwide problem that is increasing at alarming rates. It is characterized by polycystic ovaries, chronic anovulation and hyper-androgenism leading to symptoms of irregular menstrual cycles, hirsutism, acne and infertility. Insulin resistance and elevated levels of male hormones (androgens) are associated with PCOS. The sedentary lifestyle, dietary variations, lack of exercise and stress etc. are also the contributory factors. The present study was conducted to investigate the effect of Aloe vera gel and peppermint on polycystic ovary syndrome in Swiss albino. Materials and Methods:- Adult female albino mice (25-30gm) treated by one intramuscular injection of 2mg/kg body wt. with Estradiol valerate solvated in olive oil at the estrous stage for PCOS development, and were further treated with Aloe vera gel (0.5ml /mice) and peppermint(0.5ml\mice) for 30 days. Parameters that were evaluated include, estrus cyclicity. This preliminary study explores the effectiveness of Aloe vera gel and peppermint in prevention and treatment of PCOS condition. Result and conclusions:- The combination of Aloe vera gel (AVG) and peppermint extract is of interest because of its ability to regulate estrous cyclicity in PCOS-induced mice. Both herbal plants have unique features that may help restore estrous cycle regularity and improve ovarian function.
Keywords Estradiol Valerate, Clomiphene citrate, PCOS, Aloe vera gel, anovulation, anti-hyperlipidemic, estrus cycle, insulin resistance, hyperandrogenism, infertility.
Field Biology > Zoology
Published In Volume 8, Issue 1, January-February 2026
Published On 2026-01-12
DOI https://doi.org/10.36948/ijfmr.2026.v08i01.66150
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