International Journal For Multidisciplinary Research

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Rasasindura: An Integrative Review of Its Preparation Properties and Pharmacological Actions

Author(s) Dr. Rajat Ramkrishna Mungulmare, Prof. Dr. Vinod Manikrao Ramteke, Prof. Dr. Raman Shankar Belge
Country India
Abstract A clear understanding of the conceptual foundations of Rasashastra is essential for examining the various dimensions of drug design and development. Rasasindura (RS) stands out as an important formulation, widely employed in clinical practice with different anupāna. In this study, references to the drug were gathered from major classical works and examined with the aim of outlining its developmental phases. Twenty-two Ayurvedic treatises, beginning with Rasahridayatantra of the 10th century and extending up to Rasatarangini compiled in the 20th century, were scanned for descriptions of RS. In addition, published research and institutional reports were consulted to integrate contemporary findings.
The review shows that authors of Rasashastra from the 10th–12th centuries were already proficient in methods such as Gandhaka jarana and associated processes. Across the surveyed literature, thirty-nine distinct procedures for preparing RS were documented, differing in the proportion of Parada and Gandhaka (ranging from 1:¼ up to 1:6), the type of Bhavana dravya, mode of heating, and duration of preparation. The prescribed heating time varies considerably across texts, extending from about half a day to nearly a week, depending on the amount of sulfur incorporated. Recent studies have introduced modified pharmaceutical approaches and analytical tools that help in better understanding and characterizing RS. Toxicological evaluations further indicate that the formulation is safe when administered within therapeutic limits.
Keywords Rasasindura, Kupipāka, Kajjali, Pharmaceutical standardization, Ayurvedic herbo-mineral medicine.
Field Medical / Pharmacy
Published In Volume 8, Issue 1, January-February 2026
Published On 2026-01-22
DOI https://doi.org/10.36948/ijfmr.2026.v08i01.66648
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