paclitaxel-induced fixed drug eruption: a rare adverse drug reaction case report

Author(s)	Dr. Rithunandana Sreeja, Dr. Balakeshwa Ramaiah, Shaik Faisal Ahmed, Aditya majumder
Country	India
Abstract	Fixed drug eruption (FDE) is a delayed cutaneous adverse drug reaction characterized by well-defined erythematous to hyperpigmented lesions that recur at the same site upon re-exposure to the offending drug. Although commonly associated with antibiotics and non-steroidal anti-inflammatory drugs, chemotherapeutic agents are rarely implicated. Paclitaxel, a taxane widely used in the treatment of breast cancer, is associated with several cutaneous adverse effects; however, paclitaxel-induced fixed drug eruption is rare. We report a case of fixed drug eruption secondary to paclitaxel in a patient with metastatic breast cancer. The reaction was clinically evaluated by a dermatologist and systematically documented, assessed, and reported through adverse drug reaction monitoring and pharmacovigilance practice.
Keywords	Fixed drug eruption, Paclitaxel, Adverse drug reaction, Pharmacovigilance, Breast cancer
Field	Medical / Pharmacy
Published In	Volume 8, Issue 1, January-February 2026
Published On	2026-01-15
DOI	https://doi.org/10.36948/ijfmr.2026.v08i01.66682

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