Enhanced Antibacterial Activity of Cerium Oxide Nanoparticles in Skin Ointments for Treating Acne Vulgaris

Author(s)	Pankaj Kumar Lodh, Anshul Chaubey, Nirbhik Karan, Dev Sharan Chaturvedi
Country	India
Abstract	This research successfully developed CeO₂ nanoparticle ointments for acne treatment and achieved all major objectives. The chemical co-precipitation method produced high-quality nanoparticles with 85-92% yield, showing pale yellow color and free-flowing powder texture suitable for pharmaceutical use. Transmission electron microscopy confirmed perfect 20 nm spherical primary particles with clear crystal lattice fringes, while scanning electron microscopy revealed stable 80-120 nm secondary clusters ideal for cream formulation. Dynamic light scattering measurements demonstrated excellent stability with hydrodynamic diameters of 85 nm in water and 120 nm in sweat-like conditions, maintaining low polydispersity (PDI <0.3) and strong negative zeta potential (-22 to -28 mV).
Keywords	Antibacterial, Cerium Oxide Nanoparticles, Skin Ointments, Acne Vulgaris, reactive oxygen species, Chemical Vapor Deposition, Transmission Electron Microscopy, Scanning Electron Microscopy, Dynamic Light Scattering, Reinforced Clostridial Medium, Minimum Inhibitory Concentration, Minimum Bactericidal Concentration
Field	Medical / Pharmacy
Published In	Volume 8, Issue 1, January-February 2026
Published On	2026-01-22
DOI	https://doi.org/10.36948/ijfmr.2026.v08i01.67333

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