International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Vitamin D Deficiency and Geroscience: Systemic Mechanisms Underlying Multi-organ Aging of the Skin, Liver, Brain, and Kidney

Author(s) Ms. Vishnupriya J
Country India
Abstract Vitamin D functions as a steroidal prohormone essential for calcium-phosphate balance and systemic cellular regulation. Increasing evidence reveals its integral role in the homeostasis of multiple organ systems, particularly the skin, kidneys, brain and liver as described here. Deficiency of vitamin D is now recognized as a multifaceted disorder arising from both intrinsic and extrinsic etiopathogenic factors. Cutaneous insufficiency in 7-dehydrocholesterol conversion due to aging, limited ultraviolet B exposure, or melanin pigmentation leads to reduced synthesis of cholecalciferol, causes of various dermatological diseases. A decline in collagen production as aging proceeds with few metabolism are discussed here. Hepatic dysfunction impairs 25-hydroxylation, while chronic renal disease compromises 1α-hydroxylase-mediated activation to calcitriol. The aging of organs are interdependent on each other as liver and brain discussed here. Furthermore, diminished vitamin D receptor (VDR) signaling and altered neurosteroid activity in the central nervous system are implicated in neuroinflammation, oxidative stress, and cognitive decline. The cumulative impact of these mechanisms contributes to metabolic derangements, immune dysregulation, and accelerated multi-organ aging. This review reveals the understanding of cross-talk between these organ systems and the underlying molecular pathways of vitamin D metabolism provides a foundation for novel therapeutic targets and precision-based interventions in chronic disease and geroscience
Keywords Calcitriol, Neurosteroid, Geroscience, Vitamin D receptor.
Field Biology > Bio + Chemistry
Published In Volume 8, Issue 1, January-February 2026
Published On 2026-01-31
DOI https://doi.org/10.36948/ijfmr.2026.v08i01.67486
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