International Journal For Multidisciplinary Research

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Silver Nanoparticles of Moringa oleifera - A Comprehensive Study on Antioxidant, Anti-Inflammatory and Cell Line Based Anticancer Properties.

Author(s) Dr. Radhika Sakthivel, Dr. Meera Murugesan, Ms. Rohini S
Country India
Abstract Abstract
Silver nanoparticles (AgNPs) have gained considerable attention as potential therapeutic agents owing to their notable antioxidant, anti-inflammatory, and antitumor activities. The present study focuses on the eco-friendly synthesis of AgNPs utilizing Moringa oleifera flower extract and explores their biological properties. The formation of AgNPs was confirmed by UV–visible spectroscopy, which exhibited a characteristic surface plasmon resonance peak at 430 nm. The antioxidant potential of the synthesized AgNPs was evaluated using standard in vitro assays, demonstrating effective free radical scavenging activity with a maximum inhibition of 54.63 % inhibition at a concentration of 1000μg/ml, indicating their ability to mitigate oxidative stress implicated in chronic disorders such as diabetes and cardiovascular diseases. Additionally, the AgNPs exhibited significant anti-inflammatory activity, achieving 64.70 % inhibition at 100μg/ml, suggesting their therapeutic relevance in inflammatory conditions. The anticancer activity of the synthesized AgNPs was evaluated using the MTT assay against the MCF-7 human breast cancer cell line. The results, based on absorbance measurements, revealed a concentration-dependent effect on cell viability. At the lowest concentration tested (7.8 µg/ml), MCF-7 cells exhibited higher cell viability (63.37%), indicating minimal cytotoxicity. However, with increasing concentrations of AgNPs (1000μg/ml), a gradual decrease in absorbance and cell viability (31.42%) was observed, reflecting reduced metabolic activity and enhanced cytotoxic effects. These findings provide a valuable foundation for future preclinical investigations and suggest that green-synthesized AgNPs could contribute to the development of novel therapeutic strategies for cancer and other chronic diseases.
Keywords Keywords Inflammation, oxidative stress, silver nanoparticles (AgNPs), Moringa oleifera flower, Green synthesis, Breast cancer.
Field Biology > Bio + Chemistry
Published In Volume 8, Issue 1, January-February 2026
Published On 2026-01-29
DOI https://doi.org/10.36948/ijfmr.2026.v08i01.67585
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