International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Case Report on Cloves Syndrome with Uncertained Significance of Sotos Syndrome

Author(s) Dr. Sowjanya Gulipilli, Nalla Keerthi Reddy, Ch. Gayathri Prasanna, Ch. Deepa, G. Tulja Rani
Country India
Abstract CLOVES syndrome is an uncommon non-inherited mosaic disorder involving segmental tissue overgrowth. The acronym CLOVES stands for Congenital Lipomatous Overgrowth, Vascular malformations, Epidermal nevi, and Spinal/skeletal deformities. SOTOS syndrome, commonly referred to as Cerebral gigantism. It is marked by excessive growth before and after birth, along with the recognizable facial appearance, advanced bone development, and delays in cognitive development. A 9-year-old female presented with recurring complaints of similar nature. Clinical findings raised the suspicion of mosaic somatic overgrowth disorder, with CLOVES syndrome, Klippel-Trenaunay syndrome, and Parker-Weber syndrome as potential differentials. The combined clinical, genetic, and imaging findings illustrate the complexity of patient’s condition and coexistence of characteristics of both SOTOS syndrome and CLOVES syndromes. We aimed to describe the phenotypic considerations between CLOVES and SOTOS syndrome, and reach out the novel management for the complications and the conditions associated with these syndromes.
Keywords CLOVES syndrome, PIK3CA gene, SOTOS syndrome, NSD1 gene, Kippel-Trenaunay syndrome, Parker-Weber syndrome, Genetic investigation (pathogenic mutation), Ultrasonography, Scoliosis, Vascular overgrowth, Port-wine stains.
Field Chemistry > Pharmacy
Published In Volume 8, Issue 1, January-February 2026
Published On 2026-02-19
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E-ISSN 2582-2160
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