International Journal For Multidisciplinary Research

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Volume 8 Issue 1
January-February 2026

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Physicochemical Investigations on the Interaction of Surfactants with Drugs: a Mini Review

Author(s) Dr. Mithu Maiti Jana, Mr. Ravinder Dogra
Country India
Abstract All vertebrates, including human beings, naturally contain steroidal anionic amphiphiles, such as bile salts/biosurfactants/bile acids. Pharmaceutical products are developed using bile salts that are present in the intestines of humans as well as the animals. Surface-active substances known as surfactants can be made chemically or biologically. Surfactants, both bile salts and conventional, generate micelles, A sort of molecular arrangement that organises itself, above their critical micelle concentration (CMC). The chemical nature of hydrophilic and hydrophobic molecules, structure, temperature, the presence of electrolytes or non-electrolytes, the solvent, the type of counter ions, pH, and other factors all affect the CMC value of surfactants. When a drug is absorbed and becomes available to the body, its pharmacological activity is observed. Therefore, understanding their interactions with other substances in the system is important for understanding their role in biological systems. Before a medicine reaches its intended organ, it must first pass through a cellular membrane during use.
Several physicochemical techniques have been used to investigate the interactions of numerous pharmaceutical drugs with amino acids, carbohydrates, peptides, surfactants, and salts, among other substances, in both aqueous and non-aqueous media. The aim of this paper is to increase our understanding of the basic ideas regarding surfactant-drug interactions in order to help develop more stable and efficient pharmaceutical formulations.
Keywords Amphiphiles; Micelles; Drug; Critical micelle concentration (CMC); Pharmaceutical
Field Chemistry
Published In Volume 8, Issue 1, January-February 2026
Published On 2026-01-31
DOI https://doi.org/10.36948/ijfmr.2026.v08i01.67738
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