International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 8, Issue 1 (January-February 2026) Submit your research before last 3 days of February to publish your research paper in the issue of January-February.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 8 Issue 1
January-February 2026

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Development of a Deterministic Web Tool for Evaluation of Fixed-Dose Combinations

Author(s) Mr. Omkar Ramesh Kahane, Mr. Amit Avinash Deshmukh, Ms. Vanshita Kishor Patil, Mr. Rohak Sandip Mahajan
Country India
Abstract Fixed-dose combinations (FDCs) are widely utilised pharmaceutical products combining two or more active ingredients in a fixed ratio, developed with the aim of improving therapeutic convenience and patient adherence. However, deviations from established pharmacological principles during FDC development have resulted in formulations that lack clear evidence of benefit or introduce unnecessary safety risks. In India and other low- and middle-income countries, the prevalence of non-recommended and irrational FDCs remains substantial despite large-scale regulatory bans, reflecting gaps between policy interventions and enforcement effectiveness. Current identification of irrational FDCs is predominantly retrospective, occurring through post-marketing regulatory reviews and policy-based restrictions rather than through prospective screening at the formulation stage. This work operationalises a previously described, deterministic, rule-based pharmacological framework into an interactive web-based tool—the Predictive FDC Risk Analyzer v3.1—that provides transparent, narrative-based appraisal of mechanistic compatibility, pharmacokinetic alignment and safety overlap for two-drug combinations. The tool executes entirely within the user's browser, does not access patient-level data and explicitly restricts its intended use to educational and conceptual screening contexts without clinical validation or regulatory authority. Illustrative case examples demonstrate that the tool generates consistent, qualitative verdicts for rational, high-risk and policy-restricted combinations, reflecting the underlying rule-based logic in a transparent manner. The Analyzer serves as a structured, reproducible framework for teaching and early-stage reasoning around fixed-dose combination pharmacology, but does not provide empirical risk prediction and must not be used for clinical decision-making or regulatory submission.
Keywords Fixed‑dose combinations; Rational pharmacotherapy; Drug combinations; Pharmacological screening; Rule‑based systems; Pharmaceutical education.
Field Medical / Pharmacy
Published In Volume 8, Issue 1, January-February 2026
Published On 2026-02-04
DOI https://doi.org/10.36948/ijfmr.2026.v08i01.67906
View / Download PDF File

Share this



E-ISSN 2582-2160
CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

IJFMR DOI prefix is
10.36948/ijfmr

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 8 Isu 1Cover Page Vol 7 Isu 6Cover Page Vol 7 Isu 5

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJFMR
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us +91-9687-828-838 editor@ijfmr.com