Forensic Analysis Divulged Triprolidine in Suspected Mephedrone

Author(s)	Dr. Renuka Vivek Phadke, Keshav Shamrao Kapgate, Amulya Amol Pande, Jayesh Tarachand Kohpare, Dr. Vijay J. Thakre
Country	India
Abstract	Cathinone alkaloid is found in the khat plant and is used as a social drug by people in southern and eastern Africa. The structure of cathinone resembles amphetamine and shows psychological effects as a stimulant. Similar effects are also found in synthetically prepared 4-methyl methcathinone (Mephedrone) and come under the NDPS Act. Suspected seized drugs are sent to forensic science laboratories for detection of drugs under the NDPS ACT. During forensic examination, many times it is found that drugs are sold in an adulterated form. The present paper discussed a case where an antihistamine drug, Triprolidine, is detected in the seized sample instead of mephedrone. Triprolidine is an over-the-counter antihistamine with anticholinergic properties. During chemical analysis of the seized sample, it was found that some of the commonly used preliminary tests for detecting mephedrone give positive results. Still, further advanced analysis confirmed the presence of Triprolidine instead of mephedrone in the sample. The case thus proved that modern analytical techniques are inevitable in the forensic examination of drugs.
Keywords	Mephedrone, NDPS Act, Triprolidine, Adulteration, TLC, GC-MS.
Field	Chemistry
Published In	Volume 8, Issue 1, January-February 2026
Published On	2026-02-09

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