International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Arbutin's Interaction with GABA and SERT: A Computational Approach

Author(s) Ms. Kore Ankita Prakash, Mr. Kolekar Suraj Hanmant, Ms. Gadekar Akanksha Avinash, Dr. Chopade Atul R
Country India
Abstract Anxiety disorders represent one of the most prevalent mental health conditions globally, necessitating the development of novel therapeutic interventions with improved efficacy and reduced side effects. This study investigates the anti-anxiety potential of arbutin, a naturally occurring glycoside found in various medicinal plants, through molecular docking studies targeting gamma-aminobutyric acid (GABA) receptors and serotonin transporter (SERT). Using computational molecular docking techniques, we analyzed the binding affinity and interaction patterns of arbutin with GABA-A receptor and SERT protein structures. The results demonstrate that arbutin exhibits favorable binding
characteristics with both targets, suggesting potential anxiolytic properties. Molecular dynamics simulations further validated the stability of arbutin-receptor complexes. The binding energies obtained were -7.2 kcal/mol for GABA-A receptor and -6.8 kcal/mol for SERT, indicating strong molecular interactions. These findings provide preliminary evidence for arbutin's potential as a natural
anti-anxiety agent and warrant further experimental validation through in vitro and in vivo studies.
Keywords Arbutin, molecular docking, anxiety, GABA receptor, serotonin transporter, natural compounds, anxiolytic
Field Medical / Pharmacy
Published In Volume 8, Issue 1, January-February 2026
Published On 2026-02-12
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E-ISSN 2582-2160
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