Hypersplenism: Clinical Evaluation And Management

Author(s)	Mr Adarsh Shahi
Country	India
Abstract	Hypersplenism is a clinical syndrome characterized by splenomegaly associated with cytopenias due to increased sequestration and destruction of blood cells. It is most commonly secondary to portal hypertension, chronic liver disease, hematological disorders, and infections. Patients may present with anemia, leukopenia, thrombocytopenia, or a combination of these findings, often leading to fatigue, recurrent infections, or bleeding tendencies. Diagnosis relies on clinical evaluation, laboratory investigations, and imaging studies to identify splenic enlargement and the underlying etiology. Management focuses on treating the primary cause, with options ranging from medical therapy and interventional procedures to splenectomy in selected cases. This review provides an overview of the pathophysiology, clinical features, diagnostic approach, and current management strategies for hypersplenism.
Keywords	Hypersplenism, Splenomegaly, Portal Hypertension, Cytopenia, Splenectomy
Field	Medical / Pharmacy
Published In	Volume 8, Issue 2, March-April 2026
Published On	2026-04-05
DOI	https://doi.org/10.36948/ijfmr.2026.v08i02.68616

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