International Journal For Multidisciplinary Research

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Phytotherapy and the Gonadal Axis: A Case of Amenorrhea and Hypertension Responsive to Herbal Remedies

Author(s) Dr. Widad Moussaoui, Dr. Zineb Serhane, Dr. Sara Hassane, Prof. Dr. Amine Mohammed Essafi, Prof. Dr. Zineb El Azime, Prof. Dr. Hayat Aynaou, Prof. Dr. Houda Salhi
Country Morocco
Abstract Phytotherapy is gaining increased interest as a complementary approach in the management of reproductive endocrine disorders, particularly those involving hypothalamic-pituitary-gonadal axis dysfunction. Medicinal plants rich in bioactive compounds—such as phytoestrogens, flavonoids, and polyphenols—have been traditionally used to alleviate menstrual disorders, support fertility, and manage menopausal symptoms.
This is the case of a 30-year-old female patient with a history of secondary amenorrhea and grade 3 hypertension. Evaluation of her amenorrhea revealed an isolated hypogonadotropic hypogonadism, with a Rathke’s cleft cyst identified on hypothalamic-pituitary MRI. The patient reported resumption of her menstrual cycle following the intake of a mixture of medicinal plants, including anise, sandalwood, garden cress, and Nigella sativa. The evaluation of secondary causes of her hypertension was negative for pheochromocytoma, cushing’s syndrome, and renovascular hypertension. The assessment of the renin–aldosterone system yielded borderline results, warranting further investigations to clarify the diagnosis.
This case underscores a potential interaction between phytotherapy and the hypothalamic–pituitary–gonadal axis, suggesting possible phytoestrogenic, antihypertensive, and bone-modulating effects of certain medicinal plants. These hypotheses warrant further investigation.
Keywords Hypogonadotropic hypogonadism, Phytotherapy, Rathke’s cleft cyst
Field Medical / Pharmacy
Published In Volume 8, Issue 1, January-February 2026
Published On 2026-02-21
DOI https://doi.org/10.36948/ijfmr.2026.v08i01.68824
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