Histomorphological Assessment of Biodegradation in Collagen-hydroxyapatite and Collagen-hyaluronic Acid Composites

Author(s)	Dr. Yusupalikhodjaeva Saodat Khamidullaevna, Dr. Shomurodova Gulchekhra Khurshidovna, Dr. Radjabov Otabek Iskandarovich, Dr. Vypova Natalya Leonidovna
Country	Uzbekistan
Abstract	Endo-periodontal lesions represent a complex pathological process that combines endodontic inflammation with destruction of periodontal tissues and the alveolar ridge through communication between the root canal and periodontal pocket. Histomorphological evaluation of the biodegradation of collagen-hydroxyapatite and collagen-hyaluronic acid composites was conducted via subcutaneous implantation in 24 white outbred rats. The collagen–hyaluronic acid composite was completely degraded by week 3, exhibiting minimal hemorrhagic response and preserved dermal architecture. Meanwhile, the collagen-hydroxyapatite composite exhibited prolonged biodegradation, achieving complete resorption by week 4, accompanied by fibro-reparative reaction including intense vascularization of granulation tissue, active collagenogenesis, and dystrophic calcification of the mineral framework (p<0.05).
Keywords	endo-periodontal lesions, collagen-hydroxyapatite composite, collagen-hyaluronic acid composite.
Field	Medical / Pharmacy
Published In	Volume 8, Issue 1, January-February 2026
Published On	2026-02-20
DOI	https://doi.org/10.36948/ijfmr.2026.v08i01.68914

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International Journal For Multidisciplinary Research