International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

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Magnesium in Pediatric and Adult Health: Physiological Significance, Clinical Implications, and Therapeutic Applications – A Comprehensive Review

Author(s) Dr. Venugopal Reddy Iragamreddy
Country India
Abstract Magnesium is the fourth most abundant cation in the human body and a critical intracellular ion involved in over 300 enzymatic reactions. It plays essential roles in energy metabolism, neuromuscular transmission, cardiovascular stability, bone mineralization, immune modulation, and genomic integrity. Despite its physiological importance, magnesium deficiency remains under-recognized across pediatric and adult populations. Subclinical deficiency is associated with asthma, migraine, neurodevelopmental disorders, insulin resistance, hypertension, arrhythmias, metabolic syndrome, and increased inflammatory burden. In pediatrics, magnesium is particularly vital during periods of rapid growth, neurodevelopment, and critical illness. In adults, deficiency contributes to chronic disease progression. This review comprehensively discusses magnesium physiology, homeostasis, mechanisms of action, clinical manifestations of deficiency, diagnostic challenges, pediatric and adult therapeutic applications, safety considerations, and emerging research. Recognizing magnesium as a modifiable risk factor in several disease states may significantly improve preventive and therapeutic strategies in clinical practice.
Keywords Magnesium, Hypomagnesemia, Pediatric health, Asthma, Cardiovascular disease, Electrolytes, Micronutrients, Insulin resistance
Field Medical / Pharmacy
Published In Volume 8, Issue 1, January-February 2026
Published On 2026-02-18
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E-ISSN 2582-2160
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