A Study of Histopathological Spectrum of Lower Gastrointestinal Tract Endoscopic Biopsies in a Tertiary Care Centre

Author(s)	Dr. Priyanka Singh, Dr. Ritu Sharma, Dr. Tripti Singh, Dr. Nikhilesh Kumar, Dr. Monika Gupta, Dr. Megha Bansal, Dr. Rashi Bhargava
Country	India
Abstract	Background: Lower gastrointestinal (GI) tract lesions present with a wide spectrum of clinical manifestations. Although endoscopy allows direct visualization of mucosal abnormalities, histopathological examination remains the gold standard for definitive diagnosis. Objective: To study the histopathological spectrum of lower GI endoscopic biopsies and to correlate histopathological findings with endoscopic diagnosis. Materials and Methods: This cross-sectional study included 44 patients who underwent lower GI endoscopy followed by biopsy. Clinical details, endoscopic findings, and histopathological features were analyzed using routine hematoxylin and eosin staining. Results: The majority of lesions were non-neoplastic (90.9%), with ulcerative colitis being the most common diagnosis. Neoplastic lesions constituted 9.1% of cases, predominantly adenocarcinoma. Conclusion: Histopathological examination of lower GI endoscopic biopsies is indispensable for accurate diagnosis and appropriate management.
Keywords	Lower gastrointestinal tract, Endoscopic biopsy, Histopathology, Neoplastic, Non-neoplastic
Field	Medical / Pharmacy
Published In	Volume 8, Issue 2, March-April 2026
Published On	2026-03-16
DOI	https://doi.org/10.36948/ijfmr.2026.v08i02.70055

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