Cu-catalyzed N-arylation of anilines with phenylboronic acids

Author(s)	Dr. AMINUR KHAN
Country	India
Abstract	The C-N bonds formation methodology is very important for a many essential organic synthetic compounds. This work highlights the development of copper and DBU (1,8-diazabicyclo[5.4.0]undec-7ene) assisted N-arylation of various anilines and arylboronic acids in both stoichiometric and catalytic reactions. In the Cu-catalyzed N-arylation step, DBU acts as ligand as well as base, resulting in improved functional tolerance and higher yields than those observed with inorganic or other nitrogen bases, thus DBU assisted offering access to a variety of N-arylating product (scheme 1) with various electron donating and electron withdrawing substituents, including halogens or other reactive functional groups. The utilization of numerous aromatic amines as nucleophiles and boronic acids together with optimized reaction condition (choice of copper source, additive, base and solvent), mechanism, scope and limitations are also examined; these have high chemo-selective, milder reaction condition.
Keywords	N-arylation, C-N coupling reaction, Cu-catalyzed and DBU.
Field	Chemistry
Published In	Volume 8, Issue 1, January-February 2026
Published On	2026-02-27

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